Tenukala Aier
Christian Institute of Health Science and Research (CIHSR), IndiaPresentation Title:
Clinical and laboratory characteristics of paediatric systemic lupus erythematosus at secondary level hospital among local population in Northeast India
Abstract
Background: Systemic lupus erythematosus
(SLE) is a chronic autoimmune disease characterized by multisystem inflammation
and the presence of circulating auto antibodies directed against self- antigens
with flare-ups and remissions. Childhood- onset SLE (cSLE) is a rare disease
with an incidence of 0.3-0.9 per 100.000 children-years. The study among
paediatric population of northeast India
were few and hence this study from Northeast India
was undertaken. Objective of this study was to study the clinical and
immunological profile of children with systemic lupus erythematosus (SLE). To
study the Distribution of Renal Lesions according to ISN/RPS Classification of Lupus
Nephritis.
Methods: Retrospective observational single Centre study at
secondary care hospital in Northeast India. Medical records of children with
SLE admitted in Paediatric department from the period
of 2018-2024 through the
hospital information management were analyzed. Clinico pathological features
and immunological profile were compared with other studies.
Results: Among 20 patients studied female to male ratio was3:1. The
mean patient’s age at the time of presentation was 12.4 years. The mean
duration of illness was 8.5 months. Most common systems involved were
hematological (85%), followed by kidney (75%) and mucocutaneous (75%). All
(100%) cases were ANA positive. 45% were anti smith antibody positive, 20% were
Anti- dsDNA positive. Focal and segmental proliferative glomerulonephritis
(ISN/RPS class III) was the most commonly seen histological pattern, seen in 5
(83%) patients who underwent biopsy. Diffuse proliferative glomerulonephritis (ISN/RPS
class IV) was seen in 1
(16%) patient.
Conclusion: Childhood onset SLE is still a challenge to diagnose and manage due to unpredictable clinical manifestations with variable disease activity at different age.
Biography
Dr Tenukala Aier, is a senior consultant and Head of Department, Paediatrics, at Christian Institute of Health Science and Research (CIHSR), Dimapur, Nagaland. She holds an MBBS degree from the Regional Institute of Medical Sciences (RIMS) in Imphal, Manipur and completed her MD in Paediatrics at PGIMER & Dr. R.M.L. Hospital, New Delhi. She has 5 paper publication at national & international journals. She is actively involved in post graduate DNB teaching program and Diploma paediatric nurses critical care course. Her academic and clinical interests include paediatric rheumatology, nephrology, hematology , neonatology and social paediatrics. She is also very interested in skill training of healthcare workers especially serving in remote areas.
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